Best nutrition practices for obesity management medications

Best nutrition practices for obesity management medications

Obesity is a chronic disease that affects more than 2 in 5 U.S. adults. While obesity is commonly diagnosed based on body mass index (BMI), it’s more accurately described as the buildup of excess body fat (adipose tissue) that increases health risks.  

Obesity affects both civilians and Service Members, leading to health concerns for all and mission readiness challenges for the military. While weight-loss strategies, such as calorie-reduced diets, can be effective, some individuals may struggle to sustain them over time. However, the introduction of new obesity-management medications offers an additional treatment option for some people with obesity.   

Obesity management medications, also known as weight-loss or weight management medications, can enhance weight-loss outcomes. They act on the central nervous system, improving feelings related to hunger, fullness, and cravings, making it easier to follow a calorie-reduced diet.

Although these medications can improve outcomes, obesity care goes beyond taking your new prescription. Lifestyle changes, such as improving your diet, are essential for effective obesity treatment and lasting results. 

Obesity and Nutrition

4 evidence-based nutrition recommendations for individuals taking obesity management medications

1. Emphasize nutrient-dense foods

Obesity management medications often reduce appetite and overall food (energy) intake. Eating less can be necessary for weight loss, but nutrient deficiencies can occur if you eat foods that are low in nutrients. By focusing on nutrient-dense foods, such as fresh fruits and vegetables, whole grains, nuts, and lean proteins, you can increase the likelihood of meeting your nutrient needs while eating less. In general, this means eating well-rounded, mixed-macronutrient meals and choosing minimally processed foods. Some healthy dietary patterns include the HPRC Power Plate, the Mediterranean diet, and the Dietary Approaches to Stop Hypertension (DASH) diet.

2. Prioritize protein at each meal

Protein is a key macronutrient that supports optimal health, performance, and body composition. During calorie (energy) restriction, not getting enough protein can lead to muscle loss. Meeting your daily protein needs can help you preserve muscle mass and feel full longer, making weight loss easier to sustain. While protein recommendations specific to obesity management medications haven’t been established yet, the Military Dietary Reference Intakes (MDRIs) recommend 0.8–1.6 grams of protein per kilogram of body weight daily, emphasizing that you should aim for the higher end if you’re in a calorie deficit for weight loss purposes. Good lean protein sources include beans, lentils, soy products, seafood, eggs, and chicken. It can also be helpful to consume protein regularly (every 3–4 hours) to meet your daily needs and optimize protein synthesis and muscle building. 

3. Meet your daily fiber requirements

Dietary fiber is an essential nutrient for maintaining health and supporting sustainable weight loss. However, the Dietary Guidelines for Americans report that more than 90% of people do not meet their recommended fiber intake. Found in plant foods like whole grains, nuts, beans, fruits, and vegetables, fiber is the non-digestible carbohydrate that travels through your gut and supports a healthy digestive tract. Fiber can also help reduce the risk of heart disease, control blood sugar, and increase feelings of fullness. The recommended daily intake of dietary fiber is approximately 25–28 grams for women and 34–38 grams for men. Prioritizing high-fiber carbohydrates at each meal can help you meet your daily fiber goal.

4. Stay hydrated 

Emerging data suggest that some obesity management medications can reduce thirst and fluid intake, so it’s crucial that you drink enough fluids to support health, performance, and weight loss. Fluid needs vary by body size, environment, activity level, and other factors. General recommendations for fluid intake are approximately 3–4 liters per day for men and 2–3 liters per day for women. You can assess your hydration status daily and adjust your fluid intake accordingly, drinking more or less as needed.

Additional tips to support your health and weight loss journey 

Avoid foods and beverages that cause stomach upset. As with most medications, there’s a chance you could experience side effects when taking obesity management medications, including nausea, diarrhea, vomiting, and constipation. Foods high in fat or added sugar, fried or greasy foods, and spicy foods can cause stomach upset or worsen your symptoms. Consume smaller meals throughout the day, practice mindful eating, and avoid eating late at night to reduce the risk of stomach upset. If you experience painful or uncomfortable gut symptoms, contact your healthcare provider. 

Shape your food environment for success. Self-regulation is essential for weight loss, but external influences can undermine your efforts. The food environment—including accessibility, marketing, affordability, and convenience—plays a significant role in shaping your diet and helping you reach your goals. You can manage your food environment by planning meals to align with your goals, shopping for groceries online to avoid impulse buys, cooking at home to manage meal components, and seeking local resources that enhance food access and availability. 

Increase your physical activity. Regular and consistent physical activity supports weight loss and disease prevention. Aim to gradually progress your activity to at least 150 minutes of moderate-intensity aerobic activity per week. Choose activities such as brisk walking, cycling, swimming, or any other exercise that makes your heart beat faster and you breathe harder. As a general rule, you should be able to talk but not sing during moderate-intensity activity. Resistance training is critical for maintaining lean muscle mass while losing weight. Lifting for muscular hypertrophy (muscle growth) while maintaining a balanced nutrition strategy for weight loss involves determining the right volume (how much) and intensity (how heavy) to retain your existing muscle mass and potentially build more. Remember that some physical activity is better than none. So, even if you only have 15 minutes, get moving!

Work with health professionals. Research indicates that counseling focused on diet, physical activity, and behavior change is associated with greater weight loss success. Registered dietitians, physicians, nurse practitioners, exercise specialists, and psychologists can be allies in your journey. Service Members and their families should use providers at their installation when possible, as they’re familiar with service-specific policies and TRICARE coverage related to obesity management. The effect of obesity management medications on mood and mental health hasn’t been reported yet, so be alert to mood changes and reach out to a health professional if you need assistance. 

Keep up with care and be flexible

Obesity management medications are relatively new, and best practices are continually evolving. Recommendations and guidelines may change as research advances, so watch for new information. And follow up regularly with your healthcare provider during treatment with obesity management medications to monitor your progress and ensure safe, sustainable weight loss for optimal health and performance. 

Published on: October 31, 2025

References plus icon minus icon

Almandoz, J. P., Wadden, T. A., Tewksbury, C., Apovian, C. M., Fitch, A., Ard, J. D., . . . Neff, L. M. (2024). Nutritional considerations with antiobesity medications. Obesity (Silver Spring, Md.), 32(9), 1613–1631. doi:10.1002/oby.24067

Bray, G. A., Kim, K. K., Wilding, J. P. H., & World Obesity Federation (2017). Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obesity Reviews : an official journal of the International Association for the Study of Obesity, 18(7), 715–723. doi:10.1111/obr.12551

Busetto, L., Dicker, D., Azran, C., Batterham, R. L., Farpour-Lambert, N., Fried, M., . . . Yumuk, V. (2017). Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management. Obesity Facts, 10(6), 597–632. doi:10.1159/000481825

Centers for Disease Control and Prevention. (2022). Adult obesity facts. Retrieved 7 October 2025 from https://www.cdc.gov/obesity/adult-obesity-facts/index.html

Gigliotti, L., Warshaw, H., Evert, A., Dawkins, C., Schwartz, J., Susie, C., . . . Rozga, M. (2025). Incretin-Based Therapies and Lifestyle Interventions: The Evolving Role of Registered Dietitian Nutritionists in Obesity Care. Journal of the Academy of Nutrition and Dietetics, 125(3), 408–421. doi:10.1016/j.jand.2024.10.023

Headquarters, Departments of the Army, the Navy, and the Air Force. (2017). Army Regulation 40-25: Nutrition and menu standards for human performance optimization. Retrieved 7 October 2025 from https://www.armyresilience.army.mil/ard/images/pdf/Policy/AR%2040-25%20Nutrition%20and%20Menu%20Standards%20for%20Human%20Performance%20Optimization.pdf

Institute of Medicine. (2005). Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: The National Academies Press. Retrieved 1 September 2025 from https://nap.nationalacademies.org/read/10490/chapter/9

McKay, N. J., Kanoski, S. E., Hayes, M. R., & Daniels, D. (2011). Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 301(6), R1755–R1764. doi:10.1152/ajpregu.00472.2011

Mechanick, J. I., Apovian, C., Brethauer, S., Garvey, W. T., Joffe, A. M., Kim, J., . . . Still, C. D. (2020). Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists. Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery, 16(2), 175–247. doi:10.1016/j.soard.2019.10.025

Mechanick, J. I., Butsch, W. S., Christensen, S. M., Hamdy, O., Li, Z., Prado, C. M., & Heymsfield, S. B. (2025). Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity. Obesity Reviews : an official journal of the International Association for the Study of Obesity, 26(1), e13841. doi:10.1111/obr.13841

Mitchell, L. J., Ball, L. E., Ross, L. J., Barnes, K. A., & Williams, L. T. (2017). Effectiveness of Dietetic Consultations in Primary Health Care: A Systematic Review of Randomized Controlled Trials. Journal of the Academy of Nutrition and Dietetics, 117(12), 1941–1962. doi:10.1016/j.jand.2017.06.364

Morgan-Bathke, M., Raynor, H. A., Baxter, S. D., Halliday, T. M., Lynch, A., Malik, N., . . . Rozga, M. (2023). Medical Nutrition Therapy Interventions Provided by Dietitians for Adult Overweight and Obesity Management: An Academy of Nutrition and Dietetics Evidence-Based Practice Guideline. Journal of the Academy of Nutrition and Dietetics, 123(3), 520–545.e10. doi:10.1016/j.jand.2022.11.014

Neve, K. L., & Isaacs, A. (2022). How does the food environment influence people engaged in weight management? A systematic review and thematic synthesis of the qualitative literature. Obesity Reviews : an official journal of the International Association for the Study of Obesity, 23(3), e13398. doi:10.1111/obr.13398

Parrott, J., Frank, L., Rabena, R., Craggs-Dino, L., Isom, K. A., & Greiman, L. (2017). American Society for Metabolic and Bariatric Surgery Integrated Health Nutritional Guidelines for the Surgical Weight Loss Patient 2016 Update: Micronutrients. Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery, 13(5), 727–741. doi:10.1016/j.soard.2016.12.018

Ravussin, E., Smith, S. R., & Ferrante, A. W., Jr (2021). Physiology of Energy Expenditure in the Weight-Reduced State. Obesity (Silver Spring, Md.), 29(Suppl 1), S31–S38. doi:10.1002/oby.23095

Rosenbaum, M., & Leibel, R. L. (2016). Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring, Md.), 24(8), 1620–1629. doi:10.1002/oby.21559

Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011). Long-term persistence of hormonal adaptations to weight loss. The New England Journal of Medicine, 365(17), 1597–1604. doi:10.1056/NEJMoa1105816

Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., & Weijs, P. (2018). Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity. Nutrients, 10(5), 605. doi:10.3390/nu10050605

U.S. Department of Agriculture & U.S. Department of Health and Human Services. (2020). Dietary guidelines for Americans, 2020-2025 (9th ed.). Retrieved 7 October 2025 from https://www.dietaryguidelines.gov/

U.S. Department of Health and Human Services. (2018). Physical activity guidelines for Americans (2nd ed.). Retrieved 7 October 2025 from https://odphp.health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf

Wadden, T. A., Chao, A. M., Moore, M., Tronieri, J. S., Gilden, A., Amaro, A., . . . Jakicic, J. M. (2023). The Role of Lifestyle Modification with Second-Generation Anti-obesity Medications: Comparisons, Questions, and Clinical Opportunities. Current Obesity Reports, 12(4), 453–473. doi:10.1007/s13679-023-00534-z

Weijs, P. J. M., & Wolfe, R. R. (2016). Exploration of the protein requirement during weight loss in obese older adults. Clinical Nutrition (Edinburgh, Scotland), 35(2), 394–398. doi:10.1016/j.clnu.2015.02.016

Wharton, S., Batterham, R. L., Bhatta, M., Buscemi, S., Christensen, L. N., Frias, J. P., . . . Garvey, W. T. (2023). Two-year effect of semaglutide 2.4 mg on control of eating in adults with overweight/obesity: STEP 5. Obesity (Silver Spring, Md.), 31(3), 703–715. doi:10.1002/oby.23673

Yuen M. M. A. (2023). Health Complications of Obesity: 224 Obesity-Associated Comorbidities from a Mechanistic Perspective. Gastroenterology Clinics of North America, 52(2), 363–380. doi:10.1016/j.gtc.2023.03.006

I will apply this content to make meaningful changes in my life.

  • Strongly Disagree
  • Disagree
  • Not Sure
  • Agree
  • Strongly Agree

I will apply this content to make a meaningful impact on the lives of others.

  • Strongly Disagree
  • Disagree
  • Not Sure
  • Agree
  • Strongly Agree